Effect of immunostimulant on enhancement of the immune response of kuruma shrimp Marsupenaeus japonicus and its resistance against White Spot Syndrome Virus (WSSV)

An experiment of 45 days duration to test the efficacy of the Vibrio alginolyticus as an immunostimulant was conducted in Marsupenaeus japonicus against white spot syndrome virus (WSSV) infection, considered as one of the serious pathogens of shrimps. The shrimps were fed with the experimental diets coated with different concentrations of bacteria of 17 ml / kg feed and 10 % of animal body wt. They were challenged with WSSV to assess the increase in survival rate and growth if any due to immune enhancement. Another group of shrimp was used for drawing the haemolymph to estimate the increase in the level of prophenoloxidase activity. Samplings for the above said analysis were carried out at 15 days interval for a period of 45 days. The highest prophenoloxidase activity (39.78 with sand substrate-T1) and the highest survival rate (66.66 % with sand substrate-T1) and highest growth rate (7.04 % in 17ml/kg- with sand substrate-T1) were recorded in experimental diet (17 ml / kg feed). Hence the 17 ml / kg feed of Vibrio alginolyticus formalin killed added to the diet could be an eco-friendly and economically viable immunostimulant for penaeid shrimps

Structure in Supersymmetric Yang-Mills Theory

We show that requiring sixteen supersymmetries in quantum mechanical gauge theory implies the existence of a web of constrained interactions. Contrary to conventional wisdom, these constraints extend to arbitrary orders in the momentum expansion.Comment: 22 pages, LaTe

A Barren Landscape?

We consider the generation of a non-perturbative superpotential in F-theory compactifications with flux. We derive a necessary condition for the generation of such a superpotential in F-theory. For models with a single volume modulus, we show that the volume modulus is never stabilized by either abelian instantons or gaugino condensation. We then comment on how our analysis extends to a larger class of compactifications. From our results, it appears that among large volume string compactifications, metastable de Sitter vacua (should any exist) are non-generic.Comment: 14 pages, comments adde

DLCQ of Fivebranes, Large N Screening, and L^2 Harmonic Forms on Calabi Manifolds

We find one explicit L^2 harmonic form for every Calabi manifold. Calabi manifolds are known to arise in low energy dynamics of solitons in Yang-Mills theories, and the L^2 harmonic form corresponds to the supersymmetric ground state. As the normalizable ground state of a single U(N) instanton, it is related to the bound state of a single D0 to multiple coincident D4's in the non-commutative setting, or equivalently a unit Kaluza-Klein mode in DLCQ of fivebrane worldvolume theory. As the ground state of nonabelian massless monopoles realized around a monopole-``anti''-monopole pair, it shows how the long range force between the pair is screened in a manner reminiscent of large N behavior of quark-anti-quark potential found in AdS/CFT correspondence.Comment: LaTeX, 23 page

Prediction and management of natural disasters through indigenous Technical Knowledge, with special reference to fisheries

Traditional Indigenous knowledge has over the years played a significant role in solving several major social-ecological problems including those related to climate change and variability. People living close to nature often observe the circumstances around them and are the often the first to identify and adapt to any changes. The appearance of certain birds, mating of certain animals and flowering of certain plants are all seen as important signals of change with respect to timing and seasonality of natural phenomena that are well understood in traditional knowledge systems. Indigenous and local peoples have relied on biodiversity as a buffer against environmental variation, change and catastrophe

Is there an association between vitamin D and risk of stroke?: a North Indian study

Background: Vitamin D deficiency is present in India in epidemic proportions despite plenty of sunshine. Reduced plasma 25(OH) D concentrations as a diagnostic marker of vitamin D deficiency have been in past decade associated with several well-established risk factors for ischaemic stroke, such as arterial hypertension, thrombosis, atherosclerosis. The aims and objectives of this study was to compare the serum 25(OH) D levels between the first ever acute stroke patients and healthy controls.Methods: A cross-sectional, case control study was conducted in a tertiary care hospital in New Delhi situated in north India. Serum 25‑hydroxyvitamin D (25(OH) D) levels in 85 patients of ischemic stroke, presenting within 7 days of onset of stroke was measured and was compared with 70 age and gender matched controls.Results: The mean age was 61.02±11.58 years and 58.63±11.28 years in cases and controls respectively. Females constituted 37.6% of the total number of cases and 43.4% of the controls. The age and gender-distribution were comparable between the cases and controls. The median value (IQR) of serum 25(OH) vitamin D level was 7.94 ng/mL (4.59-14.00) in the cases and it was 8.82 ng/mL (5.59-14.70) in the controls. The difference between the serum 25(OH) vitamin D levels of the two groups was not found to be statistically significant.Conclusions: There is a high prevalence of biochemical hypo-vitaminosis D in apparently healthy Indians of all age and sex groups despite adequate sunshine. There is no association between low vitamin D levels and stroke

Linear Sigma Models with Torsion

Gauged linear sigma models with (0,2) supersymmetry allow a larger choice of couplings than models with (2,2) supersymmetry. We use this freedom to find a fully linear construction of torsional heterotic compactifications, including models with branes. As a non-compact example, we describe a family of metrics which correspond to deformations of the heterotic conifold by turning on H-flux. We then describe compact models which are gauge-invariant only at the quantum level. Our construction gives a generalization of symplectic reduction. The resulting spaces are non-Kahler analogues of familiar toric spaces like complex projective space. Perturbatively conformal models can be constructed by considering intersections.Comment: 40 pages, LaTeX, 1 figure; references added; a new section on supersymmetry added; quantization condition revisite

Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes.

This paper was originally published in PLOS ONE (Robinson KA, Hegyi K, Hannun YA, Buse MG, Sethi JK, PLoS ONE 2014, 9(10): e108963. doi:10.1371/journal.pone.0108963).Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concentrations. We have previously shown that the mTOR complex 1 (mTORC1) plays a partial role in the development of insulin resistance in this model. Here, we demonstrate that treatment with Go-6976, a widely used "specific" inhibitor of cPKCs, alleviates hyperglycemia-induced insulin resistance. However, the effects of mTOR inhibitor, rapamycin and Go-6976 were not additive and only rapamycin restored impaired insulin-stimulated AKT activation. Although, PKCα, (but not -β) was abundantly expressed in these adipocytes, our studies indicate cPKCs do not play a major role in causing insulin-resistance in this model. There was no evidence of changes in the expression or phosphorylation of PKCα, and PKCα knock-down did not prevent the reduction of insulin-stimulated glucose transport. This was also consistent with lack of IRS-1 phosphorylation on Ser-24 in hyperglycemia-induced insulin-resistant adipocytes. Treatment with Go-6976 did inhibit a component of the mTORC1 pathway, as evidenced by decreased phosphorylation of S6 ribosomal protein. Raptor knock-down enhanced the effect of insulin on glucose transport in insulin resistant adipocytes. Go-6976 had the same effect in control cells, but was ineffective in cells with Raptor knock-down. Taken together these findings suggest that Go-6976 exerts its effect in alleviating hyperglycemia-induced insulin-resistance independently of cPKC inhibition and may target components of the mTORC1 signaling pathway.This work was supported by grants from the Biotechnology and Biological Sciences Research Council (David Phillips Fellowship, JF16994), Diabetes UK (BDA:RD06/0003237) and British Heart Foundation (PG/10/38/28359) to J.K. Sethi and also from National Institute of Diabetes and Digestive and Kidney Diseases (DK-02001) to M.G. Buse

Factors influencing the likelihood of acceptance of postpartum intrauterine devices across four countries: India, Nepal, Sri Lanka, and Tanzania.

OBJECTIVE: To examine the factors that positively influenced the likelihood of accepting provision of postpartum intrauterine devices (PPIUDs) across four countries: Sri Lanka, Nepal, Tanzania, and India. METHODS: Healthcare providers were trained across 24 facilities in counselling and insertion of PPIUDs as part of a large multicountry study. Women delivered were asked to take part in a 15-minute face-to-face structured interview conducted by in-country data collection officers prior to discharge. Univariate analysis was performed to investigate factors associated with acceptance. RESULTS: From January 2016 to November 2017, 6477 health providers were trained, 239 033 deliveries occurred, and 219 242 interviews were conducted. Of those interviewed, 68% were counselled on family planning and 56% on PPIUD, with 20% consenting to PPIUD. Multiple counselling sessions was the only factor resulting in higher consent rates (OR 1.30-1.39) across all countries. Odds ratios for women's age, parity, and cadre of provider counselling varied between countries. CONCLUSION: Consent for contraception, specifically PPIUD, is such a culturally specific topic and generalization across countries is not possible. When planning contraceptive policy changes, it is important to have an understanding of the sociocultural factors at play